This study aimed to study the effect of oreganum on forced molting in laying Japanese quails to improve the physiological performance and restore the reproductive capacity of females. A total of 120 female Japanese quails (Coturnix coturnix Japonica) aged 18 weeks were divided randomly into six groups: group A – pre-molting from weeks 18 to 19; group B – supplemented with oregostim at a dose of 0.3 mL\1000 mL; group C (molting from weeks 20 to 22) – fed a restricted diet; group D – fed a limited diet with oregostim at the same dose and post-molting from week 23 to week 37; group E – fed a basal diet; and group F – fed a basal diet and treated by oregostim. The results showed that the molting group caused a significant reduction in the weight of body and ovary in group C and group D, while the weights were restored in group E and group F relative to other groups. Besides, there was a significant decrease of WBCs and RBCs count in group C and group D with a significant elevation in group E and group F compared with group A and group B. The percentage of egg production and large follicle number in group C and group D decreased significantly compared with group A and group B, while they restored to normal values in group E and group F compared with group A and group B and showed a significant increase as compared with group C and group D, respectively. We concluded from this study that oregostim does not have adverse effects on the molting period. Thus, the standard diet supplemented with oregostim was considered as a better molting technique.